The purpose of this study is to examine the role of the strategic plan of the Islamic University of Madinah (IUM) in promoting entrepreneurship through its initiatives, specifically, the Islamic University of Madinah Accelerator Program (IUMAP). This study provides insight into the experiences and track record of the IUM accelerator program’s participants. A qualitative case study was conducted, and semi-structured interviews and document analysis were the primary data collection tools. Ten entrepreneurs and four administrators of the accelerator were interviewed. A thematic analysis of both the interviews and the document was conducted. The main findings are the IUM’s focus on expanding its role from teaching Islamic science to being an entrepreneurial university and launching initiatives that develop the entrepreneurial ecosystem. Consequently, 50% of the projects of the IUMAP were able to continue. This study contributes to developing a proposed framework for a university business accelerator with four components: participants, services, essentials for success, and impact. Regarding the lattermost component, this includes business model improvements, awards, marketing projects, community engagement, and the promotion of entrepreneurship.