Indole acetic acid (IAA) is the most common, naturally-occurring, plant growth hormone of the auxin class. This study aims to investigate the heptonephro-protective effect of the aqueous extract of baobab (Adansonia digitata) against the toxicity induced by IAA in male rats. Twenty adult male rats were used in this study and were randomly subdivided into four groups 5 rats / group: Control group; IAA group, rats were orally administered with IAA (200 mg/kg b. wt.) by gavage; baobab group, rats were orally administered with aqueous extract of baobab at 200mg/kg b. wt.; baobab and IAA group, rats were administered with IAA (200 mg/kg b. wt.) and (200 mg/kg b. wt.) by gavage. The period of the experiment was 4 weeks. Serum levels of ALT, AST, total bilirubin, creatinine and urea were increased in the IAA group. Hepatic and renal lipid peroxidation product (MDA) was significantly increased, meanwhile, reduced glutathione (GSH), glutathione-S-transferase (GST) concentrations were decreased whereas glutathione peroxidase (GSH-Px) level was increased in the IAA group when compared to control group. IAA induced severe hepatic distortion, hemorrhage, and multiple extensive necrosis as well as inflammatory cell infiltration. Also, renal histological changes in outer medulla and the cortex such as interstitial edema, tubular atrophy, vacuolation, severe tubular necrosis, and interstitial inflammation were noticed. However, almost all of these adverse effects seemed to be ameliorated by oral administration of the aqueous extract of A. digitata with IAA to rats indicating the hepatonephro-protective effect of the aqueous extract of A. digitata aginist IAA induced oxidative stress in rats.