The schistosomicidal action of green tea against female Schistosoma mansoni unisexual infection was investigated. The effects of green tea on the infection were assessed by two parameters, worm recovery and histopathological changes in the liver of the host. The results revealed that the worm burden was fewer in mice treated with green tea than in non-treated mice. Hepatic histological examination of infected non-treated mice revealed that the unisexual female infection induces hepatic lobular disorganization, cytoplasmic vacuolation of the hepatic cells, Kupffer cells hypertrophy and variable degree of necrosis. In infected mice treated with green tea, the ordinary liver lobular architecture was relatively restored; most hepatocytes were unharmed and fewer cells appeared vacuolated.